Tech Comm Available Technologies :: The Research Institute at Nationwide Children's Hospital, Columbus, Ohio

Details

Project TitleSite Specific Integration of Recombinant AAV Vector Genomes by Rep68 Protein Expressed on the Surface of AAV Particles
Track Code2016-055
Short DescriptionNone
Abstract

Recombinant AAV vectors are useful tools for efficient gene delivery and expression of therapeutic genes. To allow for efficient packaging of therapeutic genes into recombinant AAV particles, the normal AAV (rep and cap) genes are removed from the viral genome and the proteins are supplied by plasmids in trans. To allow for efficient delivery of Rep protein in combination with recombinant AAV vector genomes, Researchers at Nationwide Children's Hospital have developed a novel way of delivering a functional rep protein into the nucleus for efficient integration of the AAV genome.

 
TagsAAV, vector, plasmid, recombinant, rep, cap, nucleus
 
Posted DateSep 25, 2017 3:26 PM

Researcher

Name
Scott Loiler

Manager

Name
Andrew Corris

Inquiry

Intellectual Property

Patent Number Issue Date Type Country of Filing
None None Other Patent None
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000