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Projects Sharing Researchers


  • David Brigstock
  • Li Chen
  • Hong You
  • Min Cong



Project TitleAssessment of Cirrhosis and Resolution of Liver Fibrosis Using the MicroRNA Content of Circulating Exosomes
Track Code2015-047
Short DescriptionNone

Determining the severity or progression of liver fibrosis in patients with hepatitis B virus (HBV) allows for appropriate treatment management, but current methods to determine this are highly invasive (liver biopsy) or often inaccurate (serum indices or imaging). Inventors at Nationwide Children's Hospital have developed a minimally invasive method for assessing liver fibrosis by screening for microRNA biomarkers present in circulating exosomes. In addition to defining the current state of fibrosis, this method also predicts which patients will respond to therapy and the effectiveness of therapy.

Tagsfibrosis, liver, cirrhosis, exosome, hepatitis B virus (HBV), microRNA
Posted DateSep 25, 2017 3:35 PM


David Brigstock
Li Chen
Hong You
Min Cong


Kyle Murrah


Intellectual Property

Patent Number Issue Date Type Country of Filing
62/234,581 None Provisional United States
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000